Human Pathology (MLTS2202)
BSc, Biochemistry - BCHS
Semester: Second Semester
Level: 200
Year: 2017
HUMAN PATHOLOGY MLTS2202
SECTION A MULTIPLE CHOICE QUESTIONS
1. Coagulative necrosis is found in which infection?
(a)
TB (Al 2009, AllMS May' 10)
(b)
Sarcoidosis
(c)
Gangrene
(d)
Fungal infection
2. Programmed cell death is known as:
(a)
Cytolysis
(b)
Apoptosis
(c)
Necrosis
(d)
Proptosis
3. True about Apoptosis are all except:
(b)
(a) Inflammation is presentChromosomal breakage
(c)
Clumping of chromatin
(d)
Cell shrinkage
4. True about apoptosis is all, except:
(a) Considerable apoptosis may occur in a tissue be-fore it becomes apparent in histology
(b) Apoptotic cells appear round mass of the intense-ly eosinophilic cytoplasm with dense
nuclear
chromatin
fragments (?) Apoptosis of. cells induce inflammatory reaction
(d) Macrophages phagocytose the apoptotic cells and degrade them
5. Apoptosis is associated with all of the following features except:
(a) Cell shrinkage
(b) Intact cellular contents
(c) Inflammation
(d) Nucleosome size fragmentation of nucleus
6. Liquefactive necrosis is typically seen in
(a) Ischemic necrosis of the heart
(b) Ischemic necrosis of the brain
(c) ischemic necrosis of the intestine
(d) Tuberculosis
7. All of the following are morphological features of apoptosis except
(a) Cell shrinkage
(b) Chromatin condensation
(e) lnflammation
(d)
Apoptotic
bodies
8. Morphological changes of apoptosis include
(a) Cytoplasmic blebs
(b) Inflammation
(e)
Nuclear fragmentation
(d) Spindle formation
(e) Cell swelling
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9. Metastatic calcification is most often seen in; .
(a)
Lymph nodes
(b)
Lungs
((c) Kidney
(d)
Liver
10. Cellular adaptation is maintained even after liver is partially resected. It is known as:
(a) Hyperplasia
(UP2006)
(b) Hypertrophy
(c) Metaplasia
(d) Dysplasia
11. Liquefactive necrosis is seen in:
(a) Heart
(b) Brain
(c) Lung
(d) Spleen
12. Apoptosis is
(a} Cell degeneration
(b) Type of cell injury
(c) Cell regeneration
(d) Cell activation
13. Coagulative necrosis is seen in all except
(a) Lung
(b) Liver
(c) Brain
(d) Kidney
14. AH are true about metaplasia .except
(a) Slow growth (AIIMS 1996, UP 2002)
(b) Reverse back to normal with appropriate treatment
(c) Irreversible
(d) If persistent may induce cancer transformation
15. About hyperplasia, which of the following statement is false?
(a)
fno of ceils
(b)
f total organ size
(c)
Endometrial response to estrogen is an example
(d)
All
16. Coagulative necrosis is seen in:
(a) Brain (b) Breast
(c) Liver (d) All
17. First cellular change in hypoxia:
(a)Decreased oxidative phosphorylation in mitochondria
(b) Cellular swelling
(c) Alteration in cellular membrane permeability
(d) Clumping of nuclear chromatin
(18) Example of hypertrophy is:
(a) Breast in puberty
(b) Uterus during pregnancy
(c) Ovary after menopause
(d) Liver after resection
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(19)About apoptosis, true statement is:
(a) Injury due to hypoxia
(b) Inflammatory reaction is present
(c) Councilman bodies is associated with apoptosis
(d) All of these
20.Metastatic calcification occurs in all except:
(a) Kidney
(b) Atheroma
(c) Fundus of stomach
(d) Pulmonary veins
51. Which is X-linked recessive inheritance
(a) Down syndrome is an example
(b) Retinoblastoma is an example
(c) Show female to male transmission
(d) Are determined by both environmental and genetic factors
(e) The cause is a mutation affection the long arm of X chromosome
22. Which disease is a kind of mitochondrial disorder
(a) DMD (b) MERRF (c) Hutington's disease(d) Turners syndrome (e) Asthma
23. Which gene does not involve in the cause of diabetes mellitus: (a)DRD3gene (b)HNF1
alpha (c) glucokinase
(d) mitochondrial DNA (e) IPF-1
24. Klinefelter Syndrome is
(a) The cause is a mutation affection the long arm of X chromosome
(b) It is commonly associated with congenital heart disease
(c) The cause is mtDNA damage
(d)Sexually underdeveloped
(e) Is a fatal disease
25. Which is polygene disorder:
(a) Schizophrenia (b) Cri du Chat syndrome
(c) Klinefelter Syndrome (d) LHON (e) cystic fibrosis
26. Rentinoblastoma is the tumor with
(a) Single gene disorder (b)Mutifactorial disorder
(c) Related with chromosome translocation (d) p53 mutation
(e) infectious
27. Which one is not the environmental cause for birth defect:
(a) Virus (b) Alcohol use in pregnancy
(c) Folic acid (d) Toxoplasma (e) Radiation
28. Characteristics of mitochondrial diseases:
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(e) Threshold effect (b) X-linked (c) Inherited from the father
(d) Only female can be affected (e) Affected bone and teeth
29. Which is the disorder with AR model:
fa) meningocele (b).KSS syndrome (c) Parkinson disease
(d) sickle celi anemia (e) Spina Bifida
30. Which is the infectious genetic disease:
(a) LHON (b)phocomelia (c)albinism (d) prion diseases
(e) Huntington disease
SECTION B TERM EXPLANATION & SHORT-ANSWER QUESTIONS
1. What is a Down syndrome
2. Explain the Characteristics of genetic disorders
3. Analyze the pedigree, what inheritance model do you think? Why?
a. b.
SECTION C CONSULTING
1.
Mr A and Mrs A has a new bom baby with albnism, Mr A said the baby is not his child,
because he is health. The couples fight everyday, please help them.
2.
Mrs B(29-years-old) was pregnant, and the doctor suspected that Mrs B got gestational
diabetes. Since Mrs B s mother, her brother and her grandmother had diabetes. Her mother
has to use insulin every day. Meantime, her grandfather has hypertension. Now she wants to
know her risk of diabetes and hypertension in the future, Please consult for her.
3.
Mrs C(41-year-old) was pregnant with her third child, she is healthy, and her husband(42-
year-old) is a patient of LHON. But their two children are all the patients of Down syndrome.
They plan to have a baby again. Now they need your help, please consult for them.
4.
Miss 0 has family history with hemophilia disease (XR) her grandfather and 2 uncles are
suffered from the disease. Miss D want to know if her offspring will get the disease.
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4. . W/roAlmaz is pregnant for the second time. Her first child, Abebe has disease X.
W/roAlmaz has 2 brothers, Tesfaye&Fantu, & a sister Desta. Fantu&Desta are unmarried.
Tesfaye is married to an unrelated woman called Tenagne, & has a 2 year old daughter,
Mimi. W/roAlmaz’s parents are AtoKebede& W/roBeletech. Beletech’s sister who is called
W/roKelemuwa is the mother of W/roAlmaz’s husband, AtoWorku, who is 25 years old.
There is no previous family history of disease X.
a.
Draw the pedigree using standard symbols.
b.
What is the pattern of transmission of the of disease X, & what is the risk of disease X
for W/roAlmaz’s next child?
c.
Which people in this pedigree are necessarily heterozygores?
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