Human Pathology (MLTS2202)
BSc, Biochemistry - BCHS
Semester: Second Semester
Level: 200
Year: 2019
REPUBLIC OF CAMEROON THE UNIVERSITY OF BAMENDA
Peace-Work-Fatherland
P. O. BOX 39 Bambili
School/Faculty: _SCIENCE____________ Department:_Biological Sciences
Lecturer(s): _Dr Oumar/Kada/Fotsing
Course Code: _MLTS2202_______ Course Title: _Human Pathology
Date: _05/07/2019_______Halls: __PBA07/08________Time: 8-10h__
Instructions:__Answer all questions beginning with any part of your choice.
PART I: 20 marks
SECTION A:
I-
For each of the descriptions on the left, write the corresponding letter from the list of terms on the right: use only the
numbers and letters 4.5 marks
Descriptions Terms
1 Deposition of calcium salts in dead or dying tiss
ue.
A. Atrophy
2 Is mediated by activation of caspases
B.
Hypertrophy
3 Increase in the size of cells/tissues.
C. Hyperplasia
4 Replacement of one cell type with another
D. Apoptosis
5 Decrease in the size of cells/tissues.
E.(Coagulative) necrosis
6 Deposition of calcium salts in normal tissues
F. Metastatic
calcification
7 Are responsible for lipid peroxidation & DNA damage
G. Dystrophic calcification
S Adaptive increase in the number of cells.
H. Free radical
9 Results in random and diffuse DNA breakdown I. Metaplasia
SECTION B: short answers questions
1) State 5 beneficial effects of acute inflammation 2.5marks
2) Stale 4 causes of chronic inflammation 4 marks
3) In a tabular form Compare and contrast acute and chronic inflammations. 3 marks
4) Examine pedigree below.
I-1 I-2 I-3 I-4 II-1 II-2 II-3 II-4 0.5 x 8 = 4marks
PART II: 20 Marks
1. Define the following terms: bradykinesia, endothelium, hypertension, free radicals, dementia (5 Marks)
2. What is cryptorchidism? Explained why cryptorchidism can lead to male infertility (3 Marks)
3. After giving the value of the normal blood pressure, describe the different types of hypertension according to the level of the
diastolic blood pressure (4 Marks)
4. Explained the pathophysiology of Arrhythmia (3 Marks)
5. Define infertility and describe the different characteristics of male infertility (5 Marks)
www.schoolfaqs.net
PART III, (30 marks)
a)
b)
SECTION C CONSULTING
1.
Mr A and Mrs A has a new bom baby with albnism, Mr A said the baby is not his child, because he is health. The couples
fight everyday, please help them.
2.
Mrs B (29-years-old) was pregnant, and the doctor suspected that Mrs B got gestational diabetes. Since Mrs B s mother, her
brother and her grandmother had diabetes. Her mother has to use insulin every day. Meantime, her grandfather has hypertension.
Now she wants to know her risk of diabetes and hypertension in the future, Please consult for her.
3.
Mrs C (41-year-old) was pregnant with her third child, she is healthy, and her husband (42-year-old) is a patient of LHON.
But their two children are all the patients of Down syndrome. They plan to have a baby again. Now they need your help, please
consult for them.
4.
Miss 0 has family history with hemophilia disease (XR), her grandfather and 2 uncles are suffered from the disease. Miss D
want to know if her offspring will get the disease.
4. W/ro Almaz is pregnant for the second time. Her first child, Abebe has disease X. W/ro Almaz has 2 brothers, Tesfaye &
Fantu, & a sister Desta. Fantu & Desta are unmarried. Tesfaye is married to an unrelated woman called Tenagne, & has a 2
year old daughter, Mimi. W/ro Almaz’s parents are Ato Kebede & W/ro Beletech. Beletech’s sister who is cailed W/ro
Kelemuwa is the mother of W/ro Almaz’', husband, Ato Worku, who is 25 years old. There is no previous family history of
disease X.
a.
Draw the pedigree using standard symbols.
b.
What is the pattern of transmission of the of disease X, & what is the risk of disease X for W/ro Almaz’s next child?
c.
Which people in this pedigree are necessarily heterozygore
www.schoolfaqs.net
