HUMAN PATHOLOGY CA (MLTS2202)
BSc, Biochemistry - BCHS
Semester: Second Semester
Level: 200
Year: 2018
MLTS 2202 human Pathology: CA
Question 1: multiple choice question (MCQ): Select and write down only the question number and the letter
corresponding to the correct answer. 12 marks
1) Joel works out so that his muscles will undergo: a) apoptosis b) dysplasia c) hyperplasia d) hypertrophy e)
metaplasia
2) What is an example of fibrinous inflammation? a) serous pleural effusion b)bread and butter pericarditis c)
acute bacterial meningitis d) Tuberculoma e) none of the above
3) Which is NOT evidence of irreversible ceil injury? a) acute cell swelling ("cellular edema’) b) calcium chunks
in the mitochondria c) nuclear pyknosis d) rupture of the iysosomes e) all the above are evidence of irreversible
injury
4) Which is not a feature of apoptotic cell death? a) cutting of the DNA at regular intervals b) cross-linking of
proteins in the cytoplasm c) destruction of the cytoskeleton d) liquefaction of the apoptotic remnant e) pyknosis
of the nucleus as in other forms of necrosis
5) What is the name of the phenomenon where WBC's marginate and become attached to the edge of the
endothelium? A) Cementing B) pavementing C) marginaticG D)adhesion
6) The following diseases are abnormalities of sex chromosome a)The Turner syndrome b)The Patau syndrome
(Trisomy 13) c)Tne down syndrome d)The Edward syndrome (Trisomy 18) e) The sickle ceil anemia
7) The following diseases are abnormalities of autosomal chromosome except one a ) The “cri du chat’ syndrome
b)The velccardicfacial syndrome c)The down syndrome d)The klinefelter syndrome e)All of the above
8) Concerning the human genome
a)
Every cell in the human body has DNA with the same genetics information b) Different cells perform
different functions Because they have different genetics materials c) Different cells perform different
functions because they have different genetics material but use different part of it d) All the cells of the body
have 22 pairs of gonosomes and a pair of autosomes
9) Why are males more likely to exhibit an X linked recessive trait than females?
a) Male sex hormones affect expression of genes from the X chromosome, b) Most genes on the X chromosome
are net shared with the Y. c) X linked traits tend to control male secondary sexual development, d) None of the
above
10) The following factors may cause cells injury except one
a) Hypoxia and ischemia b) Immunological reaction c) Aging and genetic defects d) Mitosis and meiosis e) ail
of the above
11) The following biochemical mechanisms or substances cannot lead to ceil injury
a) Loss of energy b) Mitochondrial damage c) Defect in plasma membrane permeability d) Loss of calcium
homeostasis e) colchicine
12) Concerning the overview of the cell injury which of the following statements is correct:
a)
Cells actively control the composition of their immediate environment but not their intracellular milieu
b)
Under physiological stresses or pathological stimuli, cells are unable to undergo adaptation to achieve a new
steady state
c)
If an injury is too severe., the affected cells die
d)
None of the above is correct
13) The following diseases are environmental diseases except Life style diseases b) The disease caused by
exposure to chemicals, c) The disease cause by physical factors d) The disease cause by gene defects e) None of
the above
Question 2
1)
Define the following terms: ischemia, intima, hypoxia, arteriosclerosis 4 marks
2)
Describe the pathophysiology of arteriosclerosis 2 marks
3)
What is the principal difference between a simple partial seizure and a complex partial seizure? 1 mark
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