Structural Biochemistry 1 (BCHS3101)
BSc, Biochemistry - BCHS
Semester: Resit
Level: 300
Year: 2016
REPUBLIC OF CAMEROON
THE UNIVERSITY OF BAMENDA
Peace - work – Fatherland Box 39 Bambili, CAMEROON
School/Faculty: Science Department: Biochemistry Lecturers: Dr. Nantia & Mbouobda
Course Code: BCHS 33101 Course Title: Structural Biochemistry 1
Date: 19-09-2016 Hall: PBA 03, PBA 04 Time: 03:00 – 05:00
Instructions: Answer questions in ordering manner and do not miss different exercise
Exercise 1 (22 marks)
1-Define with one example the following: amino acid, nucleoside, lipoprotein (1.5 mrks)
2) You are given the following sequences: ECCIPES
i)
Justify the class of such molecule (1 mrk)
ii)
Name with explanation different bonds present in such molecule (2 mrks)
iii)
Give the 3 idlers nomenclature of the compound (2 mrks)
iv)
Illustrate its developed structure (3.5 mrks)
v)
Predict the action of the following agents on the molecule (0.75 x 8: 6 mrks)
a) Chymotrypsin
b) Lactase
c) Performic acid
d) Fluorodinitrobenzene
e) Carboxypeptidase
f) pH
g) Temperature
h) 20% Ethanol
vi)
Illustrate the behaviour of such compound in a steady increase alkaline solution (4 marks)
vii)
Deduce the pI of the molecule (2 mrks)
(given pKNH
2
: 9.6 pKCOOH: 1:19 pK
R
C: 8:3 pK
R
E: 4:3 pK
R
S: 13:6
Exercise 2 (13 marks) MCQ
1)
Differentiate between nucleoside and nucleotide, nucleic acid and amino acid (3 mrks)
2)
A student was given the following sapience: 5'-TCCAAGCTAACG-3’
i ) Justify the specific nucleic acid group of the molecule (1 mrk)
ii)
Does it contain a consensus sequence? Justify your answer? (2 mrks)
iii)
Give a semi-developed structure of this sequence (3 mrks)
iv)
Give mRNA resulting from this sequence (1 mrk)
3)
Give characteristics of the secondary structure of the DNA (4 mrks)
Good
luck
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